Polynucleotides (PDRN)

Polynucleotides (PDRN) are the newest breakthrough in regenerative aesthetics. These DNA fragments stimulate tissue repair, enhance hydration, and promote skin regeneration — earning them the title of "the new Profhilo" among UK practitioners.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides — the building blocks of DNA. When injected or applied to the skin, PDRN activates A2A purinergic receptors, triggering a cascade of regenerative responses. This includes increased fibroblast activity, enhanced collagen synthesis, improved blood flow, and reduced inflammation.

Unlike hyaluronic acid (which primarily hydrates) or botulinum toxin (which relaxes muscles), polynucleotides work by fundamentally improving skin biology. They "biostimulate" the skin to function more youthfully.

Clinical Evidence

Clinical trials demonstrate that PDRN treatments improve skin elasticity by 44%, hydration by 38%, and overall skin quality scores by 41% after a course of 3-4 treatments. Results continue to improve for up to 6 months post-treatment as biostimulation continues.

For Aesthetic Professionals

Polynucleotides are the fastest-growing treatment category in UK aesthetics. Patient demand is surging — searches for "polynucleotides UK" have increased by over 300% in the past year. Adding PDRN treatments to your menu positions your clinic at the cutting edge.