Exosomes vs PRP: Comparing Regenerative Skincare Technologies

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2026-03-23T19:40:21+00:00

Regenerative medicine has transformed aesthetic skincare, with two technologies leading the charge: platelet-rich plasma (PRP) and exosome therapy. Both harness the body's natural healing mechanisms, but they differ significantly in how they work, their clinical applications, and practical considerations for UK practitioners.

What Is PRP?

PRP therapy involves drawing the patient's blood, centrifuging it to concentrate platelets, and re-injecting the platelet-rich fraction into the treatment area. Platelets release growth factors upon activation, stimulating tissue repair, collagen production, and cellular regeneration. PRP has been used in aesthetics for over a decade and has a solid evidence base for skin rejuvenation and hair restoration.

What Are Exosomes?

Exosomes are nano-sized extracellular vesicles derived from stem cells. They carry a concentrated payload of growth factors, cytokines, proteins, and genetic material that can reprogram target cells. Unlike PRP, exosome therapy does not require a blood draw. The product comes ready to use, standardised and consistent from vial to vial. Skymedic's exosome range is manufactured to ISO 13485 standards with full batch traceability.

Efficacy Comparison

Emerging clinical data suggests exosomes may outperform PRP in several key areas. Regarding growth factor concentration, a single vial of exosomes contains significantly more growth factors than can be extracted from a patient's blood via PRP. In terms of consistency, PRP quality varies based on the patient's age, health, and platelet count, whereas exosomes are standardised. For onset of results, many practitioners report faster visible improvements with exosomes compared to PRP.

Practical Considerations for Clinics

PRP requires a centrifuge, blood collection equipment, and trained phlebotomy staff. Treatment time includes the blood draw and preparation process, typically adding 20-30 minutes. There are also regulatory considerations around handling blood products. Exosomes arrive ready to use with no blood draw required. Treatment time is shorter, patient comfort is greater, and regulatory requirements are simpler. The shelf-stable product is also easier to stock and manage.

Cost Analysis

While exosome products carry a higher per-unit cost than PRP kits, the total cost-per-treatment can be comparable when factoring in equipment, consumables, staff time, and treatment efficiency. Many UK clinics report higher patient satisfaction and rebooking rates with exosome treatments, improving overall revenue per patient.

Which Should You Choose?

Both technologies have a place in modern aesthetic practice. PRP remains a solid choice for practitioners who already have the infrastructure and for patients who prefer autologous treatments. Exosomes offer superior convenience, consistency, and emerging evidence of enhanced efficacy, making them the preferred choice for clinics looking to offer the latest in regenerative skincare.

Explore Skymedic's complete exosome range or register as a professional for wholesale access and clinical training.