Hyaluronic Acid in Aesthetic Medicine: From Serums to Dermal Fillers

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2026-04-11T15:08:40+01:00

Hyaluronic acid (HA) is arguably the most versatile molecule in aesthetic medicine. From topical hydration serums to injectable dermal fillers, its applications span the entire spectrum of professional skincare. This comprehensive guide explores the science, clinical applications, and latest innovations in HA-based treatments available in the UK.

The Science of Hyaluronic Acid

Hyaluronic acid is a naturally occurring glycosaminoglycan found throughout the body, with the highest concentrations in skin, joints, and eyes. A remarkable property of HA is its water-binding capacity — a single gram can hold up to 6 litres of water, making it the most effective hydrating molecule available in skincare.

In human skin, HA serves three critical functions:

Hydration — Maintains optimal moisture levels in the extracellular matrix

Structural support — Provides the scaffold for collagen and elastin fibres

Wound healing — Facilitates cell migration and tissue repair

By age 50, the body retains approximately 50% of its original HA content. This progressive loss contributes directly to visible ageing: loss of volume, decreased skin turgor, and the formation of fine lines and wrinkles.

Topical Hyaluronic Acid: Molecular Weight Matters

Not all hyaluronic acid products are equal. The molecular weight of HA determines its penetration depth and biological activity:

High Molecular Weight HA (1,000-1,400 kDa)

Forms a hydrating film on the skin surface. Excellent for immediate plumping and moisture retention. Does not penetrate the stratum corneum significantly but provides a protective barrier against transepidermal water loss (TEWL).

Medium Molecular Weight HA (100-1,000 kDa)

Partially penetrates the upper epidermis. Offers both surface hydration and some deeper moisturisation. Most commonly used in quality skincare formulations.

Low Molecular Weight HA (20-100 kDa)

Penetrates deeper into the epidermis. Stimulates keratinocyte proliferation and has been shown to promote wound healing. However, some research suggests very low MW HA may trigger inflammatory responses.

Cross-linked HA

Used in injectable dermal fillers, cross-linked HA resists enzymatic degradation by hyaluronidase, providing longevity of 6-18 months depending on the degree of cross-linking and injection site.

Hyaluronic Acid in Injectable Aesthetics

HA-based dermal fillers have revolutionised non-surgical facial rejuvenation. Key applications include:

Volume restoration — Cheeks, temples, chin augmentation

Lip enhancement — Volume, definition, and hydration

Rhytid correction — Nasolabial folds, marionette lines

Skin quality — Skin boosters for overall hydration and luminosity

Non-surgical rhinoplasty — Profile correction

Professional-grade HA fillers such as the Modelha range are manufactured under strict ISO 13485 standards, ensuring consistent cross-linking density, rheological properties, and biocompatibility.

Combining HA with Other Active Ingredients

Hyaluronic acid works synergistically with several key ingredients:

Vitamin C — HA hydrates while vitamin C protects against oxidative damage and stimulates collagen

Retinol — HA counteracts the drying effects of retinoid therapy

Peptides — GHK-Cu copper peptide combined with HA enhances both hydration and regeneration

Exosomes — Exosome treatments paired with HA deliver regenerative signals in an optimally hydrated environment

Niacinamide — Boosts HA production in the skin while strengthening the barrier

Choosing Professional-Grade HA Products in the UK

For both topical and injectable applications, quality indicators include:

1. Purity — Bacterial fermentation-derived HA (not animal-sourced)

2. Multi-weight formulations — Products containing multiple molecular weights deliver both surface and deeper hydration

3. Manufacturing certification — ISO 13485 for medical devices, GMP for cosmetics

4. Clinical evidence — Published studies supporting the specific formulation

5. Complementary actives — Enhanced with peptides, vitamins, or growth factors

Explore Skymedic's comprehensive Hyalurox serum, Hyalurox cream, and Hyalurox Deep Serum — all formulated with multi-weight hyaluronic acid in our ISO 13485 certified facility in Barcelona.

Frequently Asked Questions

Is hyaluronic acid suitable for all skin types?

Yes. HA is naturally present in all skin types and is non-comedogenic. It is particularly beneficial for dehydrated, mature, and post-procedure skin. Even oily and acne-prone skin benefits from lightweight HA serums.

Can I combine hyaluronic acid with retinol?

Absolutely — this is one of the most recommended professional combinations. Apply HA serum first to damp skin, then layer retinol on top. The HA maintains hydration and helps buffer potential retinol irritation.

How often should HA fillers be maintained?

Most HA fillers last 6-18 months depending on the product, treatment area, and individual metabolism. Regular maintenance appointments help sustain optimal results while often requiring less product over time.